Novel therapeutic compound tuftsin-phosphorylcholine attenuates collagen-induced arthritis
نویسندگان
چکیده
منابع مشابه
Tuftsin-Phosphorylcholine Maintains Normal Gut Microbiota in Collagen Induced Arthritic Mice
Rheumatoid arthritis (RA) is characterized by chronic autoinflammation of the joints, with a prevalence of about 1% in Western populations. Evidence in recent years has linked RA to changes in the gut microbiota (dysbiosis). Interestingly, helminths have been shown to have therapeutic activity in RA. Specifically, a glycoprotein containing phosphorylcholine (PC) extracted from helminths was fou...
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Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial hyperplasia. In this study we examined the role of perforin (pfp), a key molecu...
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Yun Jong Lee, Kye Yong Song, Eun Young Lee, Heun Soo Kang, Yeong Wook Song Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Department of Internal Medicine, Seoul National University College of Medicine, Department of Dermatology and Histopathology, College of Medicine, Chung-Ang University, Department of Internal Medicine, Seoul National University Hospita...
متن کاملInterleukin-19 blockade attenuates collagen-induced arthritis in rats.
OBJECTIVES RA is the most common form of inflammatory arthritis. IL-19 acts as a pro-inflammatory cytokine involved in the pathogenesis of RA. We investigated whether anti-IL-19 antibody treatment would modulate the severity of the disease in a CIA rat model. METHODS We generated a CIA model by immunizing rats with bovine type II collagen. CIA rats were s.c. treated with anti-IL-19 antibody 1...
متن کاملT-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis
INTRODUCTION T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism of action are largely undetermined. METHODS Rats with collagen-induced arthritis (CIA) were treated with T-614 (5 and 20 mg/kg) daily. Animals receiving methotrexate (1 mg/kg every 3 days) and the nonsteroidal anti-...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2016
ISSN: 0009-9104
DOI: 10.1111/cei.12745